Human Gene Therapy :: Biology Biological Genetic Essays

tender-hearted Gene TherapyAshanthi Desilva is now able to ride her bike in her suburban Cleveland neighborhood. She can play basketball with her friends or go fishing with her family. She is slightly inconvenienced by her weekly shot of the critical immune system enzyme adenosine deaminase (ADA). Ashanthi was born with a faulty broker that results in the inability for her physical structure to produce ADA, leaving her dangerously susceptible to even the weakest of infections (Brown). In 1990, researchers collected samples of Ashanthis blood, isolated some of her white blood cells, and incorporated into them a virus engineered to harbour a healthy ADA gene. These cells were then injected back into her body. She was the first patient to undergo gene therapy, and without that therapy and the weekly shots of ADA, she would have been destined for a life of isolation.Human gene therapy is the replacement of an absent or faulty gene with a functioning gene. As a result, the body is able to produce the correct enzyme or protein, thereby eliminating the cause of the disease (Gene_Therapy_Overview). There are essentially two types of gene therapy bodily cell therapy and hemipteran line therapy. Somatic cell therapy involves treating all cells of the individual, except the gametes, at the cellular level to correct an absent or malfunctioning gene. This can be accomplished in three ways ex vivo, in situ, or in vivo. Ex vivo involves removing cells from the patient, altering the genetic material, and placing them back into the patient. In situ requires the vector be placed directly into the affected tissues. In vivo gene therapy involves injecting the vector into the bloodstream. The vector then must find the target tissue and deliver the therapeutic genes. Germ line gene therapy treats the gametes or an embryo, which would be utilise in the case of in vitro fertilization. The difference between somatic and germ line gene therapy may seem to be subtle however, the a lterations obtained through germ line therapy are not only found in that generation, but are passed on to the individuals progeny. That has serious repercussions when it comes to discussing the ethics of using germ line therapy.Presently, confusable techniques are being examined for both somatic and germ line gene therapy, but germ line therapy is more difficult (Coults). This is not to say that somatic cell gene therapy is easily accomplished. One challenge facing researchers is finding a suitable vector that would safely and efficiently deliver the genetic lode into the patients genome.

Fleeting Satisfaction in Madame Bovary Essay -- Madame Bovary Essays

Fleeting Satisfaction in Madame Bovary The desire to have bray, rapture, and furore can often times be hurry and momentary where as the foundation of true love and commitment generally stands solid throughout many anformer(a)(prenominal) trials. In Madame Bovary (1857), a novel written by Gustave Flaubert, the main character of the story, Emma Bovary, finds both passion and commitment in different facets yet she chooses to yield herself to the desires of her rawness and seek out passion in other men instead of staying in the comfort of commitment offered to her by her husband. Emma is first introduced in the story when her hurt father needs tending from a local physician. The doctor is Charles Bovary, whom Emma will later marry. Charles is married at the time he first visits Emmas father. However, Charles wife is doddering and frail and passes away shortly after he meets Emma. Charles then marries Emma and they move to a small town in France named Yohnville, whe re Charles sets up his practice. Early in their marriage, Charles takes Emma to a party held by the Secretary of State of France in a large chteau. After a small taste of royalty, Emma is ena more thand with the romantic feel of subsisting a royal life. She begins feeling unhappy with her marriage, complaining her husband is boring and dull compared to some of the men she had met at the party. She soon seeks out companionship with other men and eventually becomes two different mens mistress. They, however, tire of her romantic ideas and leave her. Throughout her marriage to Charles, and the different relationships she has, all Emma can see is desperation and despair, so she eventually eats poison and dies, leaving her husband and her young daughter, Berthe. ... ...irs (441). Though she may not have realized it, Emmas actions affected many more people than just herself. All Emma Bovary wanted in her life was to be love with a passionate love, and she eventually was bo th loved with commitment and loved with passion, but neither of those satisfied her longings. She compromised her standards for the one thing she desired most and eventually paid the ultimate consequence with her life. The need to feel passion and romance is not nearly worth the price of a human beings life. Madame Bovary truly discovered that the desire to have romance, rapture, and passion is often times a fleeting satisfaction whereas the foundation of true love and commitment stands solid throughout many trials. Work Cited Flaubert, Gustave. The Worlds Great Classics Madame Bovary. New York Grolier Incorporated. 1968.

Beauty And The Beast :: essays research papers

Have you ever heard something go thump in the night? Do you believe in monsters? In the movies "Beauty and the Beast" and "E.T.", the monster like characters the captured the hearts of viewers of all ages. They both involve deuce characters that ar thrusted into lifestyles that they are not used to. The beast and E.T were both unique creatures, had close relationships with humans, and were great works of fiction.      In both stories, "Beauty and the Beast" and "E.T.", the chief(prenominal) characters are unique creatures are forced into a human society, which does not always accept them for who they are. Society, in general, is against both creatures school children tease and mock Elliot virtually his new extra-terrestrial friend, and the townsfolk in "Beauty and the Beast" attempt to kill the Beast for not being human. Nobody relates to either character, seeing as they are both freaks in their respective time periods a nd locations. Nobody accepts them as being different both characters are thrown out of society like a couple of lepers for not being like ein truthbody else. Also, they are both in unique situations, the Beast because he used to be a human, and was turned into an diabolic beast by a magic spell, and E.T. was from another planet, and had no intention of ever coming to earth or meeting Elliot. Both characters are very unique in the society in which they were thrust, and neither atomic number 53 has anyone like him to go to or latch onto for understanding and support.     Both the Beast and E.T. found one person on earth who accepts them for who they are. Although the Beast captures Belle, she learns to love him and understand his situation she becomes his one true friend in a society which hates him for who what they think he is. Elliot discovered E.T. in his closet, and due to the fact he had no other real friends, naturally accepted the alien. From their initia l meeting, E.T. and Elliot became the closest of friends in the film in fact Elliot was E.T.s only human friend. Other than those two humans, nobody else attempts to understand where either creature comes from, and as a result, no one befriends them.     In addition, both E.T. and the Beast come from great works of fiction, having no fact behind their stories but both being created for no purpose other than keen entertainment.

Hitler :: essays research papers

Hitler came to power in Germany in the 1930s. His reign as Fhrer of the Third Reich is known as bingle of the darkest periods of world history. He desired to build a supreme race. He believed the Jewish race was too large and too economic bothy strong. To aid him in his quest for the supreme German race and to conquer Germanys economic woes, he waged a war of holocaust against the Jewish people and any "weak" homo beings. This became known as "Hitlers Final Solution." America has risen to one of most powerful nations in the world. The mosaic of people that make up the "melting bunch of the world" are entirely responsible for the success of this country. Diverseness unifies a nation, while prejudice and discrimination cause emotional and physical separation among the inhabitants of a country "A nation divided cannot stand." Adolph Hitler and the Nazis, however, chose to follow their theories and ideas of creating a "supreme race" despite the contradiction with the universal principles that acknowledge the power of diversity. Jews, Gypsies, Poles, Slavs, the physically and mentally disabled, Jehovahs witnesses, homosexuals, political prisoners, dissenting clergy, and others who were considered unworthy of being a member of society, all fell Nazi victims. Over eleven million diverse, innocent people were slaughtered by the Nazis as a result of their desire to create an identical race of people.Hitler believed Marxism contrived to bestow the world to the Jews. Hitler predicted the Marxists would use democracy until they got the support of the intellectual world, past they would kill the populations. Hitler believed the most powerful nation would be one that is composed of a folkish state. Hitlers folkish philosophy promotes the supremacy of the "better and stronger" and the surrender of the "inferior and weaker." He believed that unaccompanied this mightier race of people would be strong enough to withst and and overcome the problems of the future (Hitler 1 4-l 0). Hitler wanted to rid the country of religion. He felt with all its indistinct characteristics and multiple forms, it was not only insignificant for human life, but it would leadto the disintegration of mankind. He believed that he needed to eliminate the Jewish and " offensive" concepts, opinions, and aims to be able to create this folkish state. Many Germans already had strong feelings of resentment and animosity towards the Jews. Hitler provoked these feelings by convincing them that the Jews were the cause of all evil.

Free Essay on Homers Odyssey: Order vs. Chaos :: Homer Odyssey Essays

Order vs. Chaos in The Odyssey   In The Odyssey, bulls eye portrays the reoccurring theme of mold versus chaos.  This theme is particularly evident within the first twelve books of The Odyssey.  Homer shows the importance of instilling order where in that respect is chaos or confusion.  To eliominate chaos and regain order, a strong hero is needed along with the intelligence to descry a solution to the problem.  In the first twelve books of The Odyssey Homer shows the need for a cunning hero in order to restore peace where there is chaos through the suitors, the do off the coast of Scheria, the Kyklopes, and Scylla and Charybdis.   The first and most evident example of chaos in The Odyssey is the presence of the suitors.  Since Odysseus never returned form the trojan War, many suitors who sought to marry Odysseus wife, Penelope, were disrespecting Odysseus house.  The house was filled with the chaos that the suitors caused.  They were there for so long because Penelope was resistant to remarry.  While they were there, they continued to consume all(prenominal) of Odysseus possessions.  His wife is besieged with suitors and his entire house is threatening to fall.  With the absence of their king, Odysseus, in Ithica his house was being overrun by the greedy suitors.  Although order is no restored in Ithica until the end of Odysseus journey, it is hinted at what is needed to end the confusion within the first four books, or the Telemacheia.  Since Telemakhos is still too young and not fully mature enough to restore order in his fathers house, it will take Odysseus return.  Even the goddess Athena recognizes the need for Odysseus warrior strength and intelligence when she says, bitterly you need Odysseus, then gamey time he came back to engage these upstarts.  I wish we saw him standing helmeted there in the door mood, holding shield and spear, looking the way he did when I first knew him. (The Odyssey, Homer, Robert Fitzgeralds translation, pp. 9)â&157 The rest of the books in this section are dedicated to Odysseus journey home so that he can restore order to his homeland and be with Penelope.   Homer also shows that a cunning hero is needed when faced with chaos in the episode where Odysseus is stuck in a storm off the coast of Scheria.

Electrolux Acquiring Zanussi Essay -- GCSE Business Marketing Coursewo

Electrolux Acquiring ZanussiElectrolux The Acquisition and Integration of Zanussi1) How would you describe the key characteristics of Electrolux and Zanussi in 1983, in terms of strategy, organization, capabilities, and performance?International sciences stool become an exceedingly most-valuable vehicle for growth for multinational companies. In this case, and because of the particular industry in which Electrolux operated in, the trend of the whole appliance industry was veneer a grand period of crisis. Although Electrolux was and still is one of the largest manufacturers of white appliances, many other manufacturers were now taking market share away from the Swedish company. For example, Philips and sec were now introducing a complete and economic line of brand new appliances. Electroluxs core contrast was vacuum cleaners and absorption-type refrigerators. Electrolux was and still is the typical Swedish firm, which emphasizes on down to existence management e veryone works and keeps his word and all the information is correct. The firm emphasis on technology and advancement and the middle management is untied to advises from the workers.But at the core of Electrolux business strategy was the aggressive plan to expand through acquisitions. First, Electrolux concentrated on acquiring firms in the Scandinavian Area. whence the company keep focusing in purchasing companies that had assets but were not profitable so that they could turn their business around. After making more than cc acquisitions in 40 countries, Electrolux was certainly one of the most experienced companies on the global scene as far as acquisition. But another important aspect of Electrolux, which helped them, maintaining leaders was the companys great flexibility concerning new products and especially their attitude towards that company which excelled in some business where Electrolux was weaker. The greatest example of this was when the company purchased Husqvarna, a chain motto manufacturer, and how in little time, through this wise take over, Electrolux found itself as the world leader in chain saw manufacturers.Electrolux never went looking for acquisition or bankrupt companies their policy was to keep their eyes open that things will come by themselves. When Electrolux was ready to clear a company, the financial statements of that company were very important. ... ...on products, ranging from refrigerators to vacuum cleaners to chain saws, in more than 150 countries.After 1988, Electrolux acquired more companies, not only for product expanding upon but also for expansion in emerging markets. Electrolux grew steadily and its sales amount to SEK117 billion in 1999 comparing to 67 billion in 1987. Electrolux signed an engagement with sharp to denounce its products in the Japanese market. In 1990 they expanded its presence in the US outdoor product market by acquiring Allegretti & Co. In 1991 they also acquire Lehel, a Hungarian white goods company, an d they introduce the low energy line of refrigerators. By this date Leif Johansson is appointed president. 1994 was the 75th birthday for Electrolux. In 1996 they expanded in Brasil by acquiring Refripar and the next year the company announced a major restructuring plan with the purpose of improving its profitability. By 1998, Electrolux got out of the business of sewing machines, agricultural implements, interior decorating equipment, kitchen and bathroom cabinets and heavy-duty laundry equipment. Now, Electrolux core business consists of household appliances, professional appliances and outdoor products. Electrolux Acquiring Zanussi hear -- GCSE Business Marketing CoursewoElectrolux Acquiring ZanussiElectrolux The Acquisition and Integration of Zanussi1) How would you describe the key characteristics of Electrolux and Zanussi in 1983, in terms of strategy, organization, capabilities, and performance?International acquisitions have become an extremely important ve hicle for growth for multinational companies. In this case, and because of the particular industry in which Electrolux operated in, the trend of the whole appliance industry was facing a long period of crisis. Although Electrolux was and still is one of the largest manufacturers of white appliances, many other manufacturers were now taking market share away from the Swedish company. For example, Philips and Siemens were now introducing a complete and economic line of brand new appliances. Electroluxs core business was vacuum cleaners and absorption-type refrigerators. Electrolux was and still is the typical Swedish firm, which emphasizes on down to earth management everyone works and keeps his word and all the information is correct. The firm emphasis on technology and advancement and the middle management is open to advises from the workers.But at the core of Electrolux business strategy was the aggressive plan to expand through acquisitions. First, Electrolux concentrated on acqui ring firms in the Scandinavian Area. Then the company continued focusing in purchasing companies that had assets but were not profitable so that they could turn their business around. After making more than 200 acquisitions in 40 countries, Electrolux was certainly one of the most experienced companies on the global scene as far as acquisition. But another important aspect of Electrolux, which helped them, maintaining leadership was the companys great flexibility concerning new products and especially their attitude towards that company which excelled in some business where Electrolux was weaker. The greatest example of this was when the company purchased Husqvarna, a chain saw manufacturer, and how in little time, through this wise take over, Electrolux found itself as the world leader in chain saw manufacturers.Electrolux never went looking for acquisition or bankrupt companies their policy was to keep their eyes open that things will come by themselves. When Electrolux was ready to acquire a company, the financial statements of that company were very important. ... ...on products, ranging from refrigerators to vacuum cleaners to chain saws, in more than 150 countries.After 1988, Electrolux acquired more companies, not only for product expansion but also for expansion in emerging markets. Electrolux grew steadily and its sales amount to SEK117 billion in 1999 comparing to 67 billion in 1987. Electrolux signed an agreement with sharp to sell its products in the Japanese market. In 1990 they expanded its presence in the US outdoor product market by acquiring Allegretti & Co. In 1991 they also acquire Lehel, a Hungarian white goods company, and they introduce the low energy line of refrigerators. By this date Leif Johansson is appointed president. 1994 was the 75th birthday for Electrolux. In 1996 they expanded in Brasil by acquiring Refripar and the next year the company announced a major restructuring plan with the purpose of improving its profitability. By 1998, Electrolux got out of the business of sewing machines, agricultural implements, interior decorating equipment, kitchen and bathroom cabinets and heavy-duty laundry equipment. Now, Electrolux core business consists of household appliances, professional appliances and outdoor products.